Certainly, load times for the game seem to increase the longer you play it without shutting the game off but this seems to be a memory/caching issue that's somewhat present on the PC version as well (i.e. The issue isn't just the load times either. Sure it's at 720p and seems to lack AA (though it's hard to tell since it's being upscaled) but I would venture that it's comparable to 'Medium' settings on the PC version with a pretty good draw distance. To start things off, I have to say that the issue is not with the quality of the graphics as the 360 version of New Vegas looks pretty good. Though it's not a big surprise that New Vegas was a superior experience on the PC (all of Bethesda's past multi-platform games have been), the difference I feel was much more significant this time around than it was previously.
So after about 35 hours of gameplay, I have to say that I'm really glad I have a good PC to play games on.
So, considering that I'm spending the holidays with my parents' house which is currently lacking a good PC (I'll be building a new one for them tomorrow), but have brought along my 360 (which apparently the TSA agents had to inspect separately?) and the fact that I was going to play it on the 360 anyway I decided to pick up NV for $40 from Amazon (Amazon Prime baby!).